Masao Hisadome Selected Research

Y 39041

7/2006	Y-40138, a multiple cytokine production modulator, protects against D-galactosamine and lipopolysaccharide-induced hepatitis.
11/2005	Treatment with Y-40138, a multiple cytokine production modulator, inhibits lipopolysaccharide- or tumour necrosis factor-alpha-induced production of pro-inflammatory cytokines and augments interleukin-10.
10/2005	Therapeutic administration of Y-40138, a multiple cytokine modulator, inhibits concanavalin A-induced hepatitis in mice.
8/2004	Combination benefit of a pyrimidylpiperazine derivative (Y-40138) and methotrexate in arthritic rats.

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Masao Hisadome Research Topics

Disease

3	Hepatitis 07/2006 - 10/2005
2	Liver Diseases (Liver Disease) 07/2006 - 10/2005
1	Alcoholic Hepatitis 07/2006
1	Acute Liver Failure (Fulminant Hepatic Failure) 07/2006
1	Necrosis 11/2005
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 10/2005
1	Arthritis (Polyarthritis) 08/2004
1	Rheumatoid Arthritis 08/2004

Drug/Important Bio-Agent (IBA)

4	Y 39041IBA 07/2006 - 08/2004
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2006 - 08/2004
3	CytokinesIBA 07/2006 - 10/2005
2	ChemokinesIBA 07/2006 - 10/2005
2	GalactosamineIBA 07/2006 - 11/2005
2	LipopolysaccharidesIBA 07/2006 - 11/2005
2	Interleukin-10 (Interleukin 10)IBA 07/2006 - 11/2005
2	Concanavalin AIBA 11/2005 - 10/2005
1	Alanine Transaminase (SGPT)IBA 07/2006
1	Pentoxifylline (Trental)FDA LinkGeneric 10/2005
1	acetamideIBA 08/2004
1	Methotrexate (Mexate)FDA LinkGeneric 08/2004

Therapy/Procedure

1	Intraperitoneal Injections 11/2005
1	Intravenous Injections 11/2005
1	Therapeutics 08/2004